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KMID : 0370019990130000041
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Chung-Ang Journal of Pharmacal Sciences
1999 Volume.13 No. 0 p.41 ~ p.45
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Effects of TMB-8 and W-7 on Signal Pathway of Phospholipase C-Ca^2+ Mobilization Induced by Endothelin-1
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Abstract
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Phospholipase C activity and intracellular Ca^2+ concentration were measured to investigate effects of TMB-8 and calmodulin antagonist on signal pathway of phospholipase C-Ca^2+ mobilization induced by endothelin-1. Activation of phospholipase C and increase in intracellular Ca^2+ concentration by endothelin-1 were dependent on extracellular Ca^2+ concentration. Both TMB-8, a intracellular Ca^2+ release blocker, and W-7, a calmodulin antagonist, significantly increased phospholipase C activity induced by endothelin-1, whereas did not elevate the intradcellular Ca^2+ concentration. This result suggests that both TMB-8 and W-7 have dual effects on signal pathway of phospholipase C-Ca^2+ mobilization induced by endothelin-1.
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